The Wright-Fisher Model and Genetic Drift
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Generalized population models and the nature of genetic drift.
The Wright-Fisher model of allele dynamics forms the basis for most theoretical and applied research in population genetics. Our understanding of genetic drift, and its role in suppressing the deterministic forces of Darwinian selection has relied on the specific form of sampling inherent to the Wright-Fisher model and its diffusion limit. Here we introduce and analyze a broad class of forward-...
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The Wright-Fisher model is the most popular population model for describing the behaviour of evolutionary systems with a finite population size. Approximations have commonly been used but the model itself has rarely been tested against time-resolved genomic data. Here, we evaluate the extent to which it can be inferred as the correct model under a likelihood framework. Given genome-wide data fr...
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We investigate the detailed connection between the Wright-Fisher model of random genetic drift and the diffusion approximation, under the assumption that selection and drift are weak and so cause small changes over a single generation. A representation of the mathematics underlying the Wright-Fisher model is introduced which allows the connection to be made with the corresponding mathematics un...
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The Wright Fisher model of evolution attempts to simulate genetic drift wherein each individual in a generation produces an infinite and equal amount of gametes. The subsequent generation is a random draw of 2N gametes from this pool. In other words, the gene frequency in the next generation is composed of 2N draws from the gene frequency of the current generation. Mutations are randomly droppe...
متن کاملStatistical Inference in the Wright–Fisher Model Using Allele Frequency Data
The Wright–Fisher model provides an elegant mathematical framework for understanding allele frequency data. In particular, the model can be used to infer the demographic history of species and identify loci under selection. A crucial quantity for inference under the Wright–Fisher model is the distribution of allele frequencies (DAF). Despite the apparent simplicity of the model, the calculation...
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تاریخ انتشار 2015